As a vape shop or convenience store owner, you are well aware of the challenges that harsh regulations have thrown at your business. And depending on your market, you may be aware of products like Spree Bar, Nixodine, NoNic6, Kumi, and other alternative products. Below we have provided a quick guide to the major competitors in this space. 

All products listed below intended for adults (21+) and may be habit forming. Refer to each manufacturer’s warnings. Local regulations are subject to change. 

Nixodine by Bonguard Naturals

Bonguard Naturals Nixodine™ is a patented formula. It is for adult smokers and nicotine vapers above the age of 21. Nixodine is designed to deliver satisfaction like traditional nicotine vapes for adult user and is compatible with existing electronic vaping devices that use traditional VG/PG e-liquid formulations and flavors.

As a new product, Nixodine continues to be extensively tested for toxicity and long-term impact. According to Bongard Naturals, on the basis of this testing: “There is evidence to suggest it (Nixodine) contains less hazardous chemicals than traditional nicotine vaping or combustible cigarettes.” Wholesale customers with additional questions can contact Bonguard Naturals for additional testing information. 

Disposable vapes are the most popular product with adult nicotine vapor consumers. There are a number of advanced Nixodine disposable vapes from trusted brands available on the market. Between the patents and partnerships with trusted brands, Nixodine is pursuing the future of vaping in an above board and fully accountable manner. 

Forms of Nixodine

The most commercially popular version of Nixodine is Nixodine-S, which is for use in vaping devices. 

• Nixodine-S is available diluted in either propylene glycol (PG) or vegetable glycerin (PG) for compatibility with current vaping hardware and disposables.
• Nixodine-S Salts is designed to meet the expectations of adult customers by providing a vaping experience that matches disposable vapes, nicotine salts and prefilled vape pods. 
• Nixodine-S is formulated to provide an experience akin to traditional vape juices. 
• Nixodine-S Polacrilex is a Nixodine powder. It is high-quality, soluble, and would works with products like pouches, lozenges, digestibles and more according their website. 
• Nixodine Pure is the the active ingredient without the additional formulations used to make it suitable for vaping products or the powdered Polacrilex form. 

Nixodine-S Salts, which mimics the vaping experience of nicotine salts is found in disposable vapes and prefilled pods.

Nixodine has less of a throat hit than freebase nicotine or nicotine salts, allowing flavors to really shine with pure clarity. There is also a standard Nixodine-S for lower potency vape juices used in vape mods. In the future, Nixodine-S Polacrilex may appear more frequently in pouches and lozenges. There is also pure Nixodine not mixed into a VG/PG base. 

Nixodine Patents

• Nixodine Patents
  

Nixodine Products

• Fifty Bar 20K Nixodine - Up to ~20,000 puffs; ~18mL total capacity, USA assembled with e-liquid flavors from US master formulators.
• Hotbox Elite 50K - Up to ~50,000 puffs; ~30mL total capacity, three modes and airflow control.
• Lost Mary MT35K Nixodine - Up to ~35,000 puffs; ~22mL total capacity, authentic Lost Mary vaping experience.
• Katchmi Disposable - Up to ~20,000 puffs; ~16mL total capacity, dual modes and built-in USB-C cable.
• Mi-Pod NX Nixodine Pods - Draw-activated pod kit for gas station and convenience store customers.  
  • Mi-Pod NX Blade: Battery 
  • Mi-Pod NX Pedal: Compact nano battery with 400mAh capacity. Compatible with Mi-Pod NX Nixodine pods.
  • Mi-Pod NX Pre-filled pods: 2ml Nixodine pods using Nixodine 50. Mesh coil, anti-leak coil.
• Nix Liquids: 100ml Nix Liquids bottles come in 6, 12 and 18 strength Nixodine and 30ml Nix Salts bottles come in 18, 36, and 50 strength Nixodine.

Metatine

According to the official site, Metatine is a synthetically molecule that is structurally similar to, but chemically different from, other vaping alkaloids. Notably, even though Metatine is a non-nicotine compound, vape devices that contain Metatine provide adult users with a strong sense of satisfaction, pleasure and enjoyment that is largely indistinguishable from traditional vape products.

Metanine describes the product’s regulatory status as well, “Since Metatine does not contain nicotine, is not derived from tobacco, and is not a component or part of a tobacco product, it does not fall under the regulatory purview of the FDA’s Center for Tobacco Products.”

Metanine Products

• SPREE BAR device (rechargeable) — Type-C charging, ~600 mAh battery; offered as a starter kit paired with prefilled pods.
• SPREE BAR prefilled flavor pods — ~12 mL per pod, up to ~6,000 puffs. 
  
• Juice Head iFlex Disposable Vape - 18ml disposable vape with flavor control, expected to be launched in Q4 2025. 

NoNic6

Kumi Six states NoNic6™ is a non-nicotine compound used as a substitute for nicotine—close in structure but chemically distinct from other vaping alkaloids, not derived from nicotine or tobacco—and is the active ingredient in Kumi 6 devices for adult users. 

NoNic6 Products

• Kumi 6: Up to ~10,000 puffs; ~16 mL e-liquid; rechargeable; battery indicator. 
• Kumi 6 Kurve: Up to ~35,000 puffs; ~28 mL e-liquid; dual-mesh; ~900 mAh.
• Kumi 6 Scenic: Up to ~50,000 puffs; ~22 mL total capacity (visible tank + prefill); digital screen.